Role of Polylactic Acid in Bone Regeneration –A Systematic Review
نویسندگان
چکیده
Bone regeneration is a complex, physiological process of bone formation, which can be seen during normal fracture healing, and is involved in continuous remodeling throughout adult life. However, there are complex clinical conditions in which bone regeneration is required in large quantity, such as for skeletal reconstruction of large bone defects created by trauma, infection, tumor resection and skeletal abnormalities. The use of bone grafts is the standard to treat skeletal fractures, or to replace and regenerate lost bone. The most commonly used is auto graft, its use can lead to complications such as pain, infection, scarring, blood loss, and donor-site morbidity. An ideal bone graft or scaffold should be made of biomaterials that imitate the structure and properties of natural bone. However, creating living tissue constructs that are structurally, functionally and mechanically comparable to the natural bone has been a challenge so far. An electronic search was conducted for articles in PubMed database to screen for articles from 1966 to sept 2014 discussing the role of polylactic acid in bone regeneration using selected keywords. Critical appraisal was done for selected articles, Search yields a total of 383 articles of which 318 full text article were obtained, 30 articles were selected after reading the abstract out of which 10 met the inclusion criteria and 308 were excluded and hand search was done with the reference of the selected articles. The article selected used polylactic acid for bone regeneration. The present Systematic review indicates, when polylactic acid is modified with osteoinductive material such as beta tricalcium phosphate and hydroxyl appetite crystals shows better acceptance than plain polylactic acid.
منابع مشابه
In vitro and In vivo Investigation of poly(lactic acid)/hydroxyapatite nanoparticle scaffold containing nandrolone decanoate for the regeneration of critical-sized bone defects
Objective(s): Bone tissue engineering is aimed at the fabrication of bone graft to ameliorate bone defects without using autografts or allografts. Materials and Methods: In the present study, the coprecipitation method was used to prepare hydroxyapatite (HA) nanoparticles containing nandrolone. To do so, 12.5, 25, and 50 mg of nandrolone were loaded into poly(lactic acid) (PLA)/nano-HA, a...
متن کاملEmerging Perspectives in Scaffold for Tissue Engineering in Oral Surgery
Bone regeneration is currently one of the most important and challenging tissue engineering approaches in regenerative medicine. Bone regeneration is a promising approach in dentistry and is considered an ideal clinical strategy in treating diseases, injuries, and defects of the maxillofacial region. Advances in tissue engineering have resulted in the development of innovative scaffold designs,...
متن کاملMechanisms of spinal cord injury regeneration in zebrafish: a systematic review
Objective(s):To determine the molecular and cellular mechanisms of spinal cord regeneration in zebrafish. Materials and Methods: Medical databases of PubMed and Scopus were searched with following key words: Zebrafish; spinal cord injuries; regeneration; recovery of function. The map of mechanisms was performed using Xmind software. Results: Wnt/ß-catenin signaling, L1.1, L1.2, Major vault prot...
متن کاملGuided bone regeneration: A literature review
Guided bone regeneration (GBR) is a reconstructive procedure of alveolar ridge using membranes. This procedure is indicated when there is no sufficient bone for implantation, or in the case of optimal implant installation for esthetic or functional needs. GBR can be performed before implant placement, when there is not enough bone for initial stability of implants and less predictable outcomes ...
متن کامل